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KMID : 0603519970020010038
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Journal of Korean Association of Cancer Prevention
1997 Volume.2 No. 1 p.38 ~ p.44
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Anticancer Activities of Plant Triterpenoids, Ursolic Acid and Oleanoic Acid
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Kim Kyu-Won
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Abstract
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In order to determine whether triterpenoids have anticancer activities, we initially studied the tumor-cell differentiating activity by using F9 teratocarcinoma stem cells as a model system. The triterpene acids, ursolic acid (UA) and oleanolic acid (OA), brought about a morphological alteration of F9 stem cells into the differentiated state. This strikingly resembles the differentiation of parieral endoderm-like cells by retinoic acid. These results present the possibility that F9 stem cells were induced to differentiate by these agents. Moreover. UA and OA inhibited embryogenic angiogenesis on the chick embryo CAMs. In addition, UA has an inhibitory effect on the invasive activity of the HT1080 cells in a concentration-dependent manner. Taken together, we suggest that triterpenoids including UA and OA have various anticancer activities-such as the induction of tumor cell differentiation, antiangiogenic activity, and anti-invasive activity.
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KEYWORD
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Anti-invasive activity, Triterpenoid
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